Patients and Methods: This was a retrospective evaluation of 13 c

Patients and Methods: This was a retrospective evaluation of 13 consecutive white male patients who underwent simultaneous mandibular vestibuloplasty with STSG combined with placement of 2 to 4 mandibular endosseous implants for construction of an implant-supported mandibular overdenture with a minimum of 2-year follow-up. Patients’ charts were evaluated for implant survival and prosthetic success.

Results: Thirteen male patients at an average age of 60.4years who had undergone simultaneous STSG mandibular vestibuloplasty and endosseous implant

placement in the anterior mandible, were followed for an average of 43 months and were retrospectively evaluated. A total of 40 implants (average learn more of 3 implants per patient) were placed in the anterior mandible in preparation for an implant-supported overdenture placement. There were no complications in graft or recipient sites, implant placement, or overdenture construction. The endosseous dental implant integration rate was 97.5% and the prosthetic

success rate was 100%.

Conclusion: Simultaneous STSG mandibular vestibuloplasty for vestibular lengthening and placement of mandibular endosseous implants in preparation for mandibular implant-supported overdentures is a reliable method in patients with shallow mandibular vestibules. (C) 2009 American Association of Oral and Maxillofacial Surgeons”
“Metallic melts above the liquidus temperature exhibit nearly Arrhenius-type temperature dependence of viscosity. On cooling below the equilibrium liquidus temperature metallic melts exhibit a non-Arrhenius temperature dependence of viscosity characterized by liquid fragility phenomenon which origin is still not well understood. Structural changes and vitrification of the Pd42.5Cu30Ni7.5P20 liquid alloy on cooling from above the equilibrium

liquidus 17DMAG price temperature are studied by synchrotron radiation X-ray diffraction and compared with the results of first-principles calculations. Subsequent analysis of the atomic and electronic structure of the alloy in liquid and glassy states reveals formation of chemical short-range order in the temperature range corresponding to such a non-Arrhenius behavior. The first-principles calculations were applied to confirm the experimental findings. (C) 2011 American Institute of Physics. [doi:10.1063/1.3624745]“
“In a patient with complaints of photophobia and an ocular deviation, straylight was found to be increased to 1.61 (log[s]), which is 5 times the normal value. The only relative clinical finding was the edge of a too small posterior capsulotomy. Visual acuity was normal. Six weeks after the posterior capsulotomy was widened to a diameter of 6.0 mm with a neodymium:YAG laser, the symptoms were resolved and the patient was satisfied. Stray light may manifest clinically as complaints of photophobia.

An electronic database search of MEDLINE, EMBASE and the Cochrane

An electronic database search of MEDLINE, EMBASE and the Cochrane Library and extensive manual GW3965 in vivo searching of articles were conducted to identify studies that have used objective measurements of BP and neuropsychological tests to investigate the relationship among hypertension, cognitive function and/or antihypertensive treatment. In total, 28 cross-sectional studies, 22 longitudinal studies and 8 randomized placebo-controlled

trials met the inclusion criteria. Cross-sectional studies showed mixed relationships between higher BP and cognition, with many studies showing no correlation or even J- or U-shaped associations. The majority of longitudinal studies demonstrated elevated BP to be associated with cognitive decline. Randomized studies demonstrated heterogeneous and, sometimes conflicting, effects of BP lowering on cognitive function. Suggested reasons for this heterogeneity include multiple mechanisms by which hypertension affects the brain, the variety of cognitive instruments used for assessment and differences in antihypertensive treatments. Although lowering the BP is beneficial in most patients with

JQ1 vascular risk factors, the effects of BP reduction on cognition remain unclear. Given the predicted upswing in people with cognitive impairments, the time is right for randomized clinical trials with specific cognitive end points to examine the relationship between cognitive function and hypertension and guide practice.”
“We assessed the associations between multimorbidity and health-related quality of life (HRQL), and healthcare utilization, based on 16 common self-reported chronic conditions.

A cross-sectional questionnaire survey including the EQ-5D was conducted in a sample of the general population of adults (a parts per thousand yen18 years) living in Alberta, Canada. Multiple linear and logistic regressions were used to assess the association between

multiple chronic conditions and HRQL, hospitalization and emergency department (ED) use.

A total of 4,946 EPZ-6438 clinical trial respondents reported their HRQL, noting problems mostly with pain or discomfort (48.0 %). All chronic conditions were associated with a clinically important reduction in HRQL, the highest burden with anxiety or depression (-0.19, 95 % CI -0.21, -0.16) and chronic pain (-0.19, 95 % CI -0.21, -0.17). Multimorbidity was associated with a clinically important reduction in the EQ-5D index score (-0.12, 95 % CI -0.14, -0.11) and twice the likelihood of being hospitalized (OR = 2.2, 95 % CI 1.7, 2.9) or having an ED visit (OR = 1.8, 95 % CI 1.4, 2.2).

Pain or discomfort is a common problem in people living with chronic conditions, and the existence of multimorbidity in these individuals is associated with a reduction in the HRQL as well as frequent hospitalization and emergency department visits.”
“Background: Missing items are common in quality of life (QoL) questionnaires and present a challenge for research in this field.

However, the causative roles of Gd remain unknown


However, the causative roles of Gd remain unknown.

Objective: The aim of this in vitro study was to investigate the effect of Gd on the development of fibrosis and calcification in cultured cells.

Methods: MC3T3-E1 cells (pre-osteoblastic cells), human adipose tissue-derived mesenchymal stem cells (HAMSCs), human subcutaneous preadipocytes,

and human dermal fibroblasts (HDFs) were buy SYN-117 each cultured in differentiation medium with or without gadolinium chloride. Calcium deposition of MC3T3-E1 cells, HAMSCs, and HDFs was determined by alzarin red S staining. Adipogenic differentiation of human subcutaneous preadipocytes and HAMSCs was determined by oil red O staining. Fibrogenesis of HDFs was determined by real-time PCR to measure the mRNA expression of type I collagen. Cell proliferation was determined by MTS assay.

Results: Gd induced calcium deposition in MC3T3-E1 cells, HAMSCs and HDFs in osteogenic differentiation media. Gd did not induce adipogenic GS-9973 molecular weight differentiation in human subcutaneous preadipocytes and HAMSCs. Gd did not increase the mRNA expression of type I collagen in HDFs, but did promote cell proliferation.

Conclusions: We have demonstrated a direct effect of Gd on calcium deposition in cultured cells. The result will help us to understand the mechanism of abnormal calcification in

NSF. (C) 2011 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.”
“A rare complication of mature cystic teratoma of the ovary is malignant transformation, mostly being squamous cell carcinoma (SCC). Due to small case series, there are no established standard surgical and postoperative procedures.

A 41-year-old pregnant woman presented with a right ovarian tumour. At 14 weeks of gestation, laparotomy with oophorectomy was performed. Histology revealed a pT1a poorly differentiated SCC

with lymphovascular invasion. She delivered a healthy infant at 39 weeks of gestation. Nine weeks after delivery, Autophagy inhibitor she underwent complete surgical resection and was staged pT1a, pN0 (0/40) pMx, G0. No further treatment was given and 37 months later she is still free of disease.

For this rare entity complete surgical resection seems to be a safe treatment.”
“Background: Polycystic ovary syndrome (PCOS) is the most common chronic endocrine disorder affecting women of reproductive age. This study aimed to compare the HRQoL of South Asian and white Caucasian women with PCOS, given that it is particularly common among women of South Asian origin and they have been shown to have more severe symptoms.

Methods: The Polycystic Ovary Syndrome Questionnaire (PCOSQ) and the Short Form-36 (SF-36) were administered in a cross-sectional survey to 42 South Asian and 129 Caucasian women diagnosed with PCOS recruited from the gynaecology outpatient clinics of two university teaching hospitals in Sheffield and Leeds.

The NT-proBNP concentration was significantly higher in the nonre

The NT-proBNP concentration was significantly higher in the nonresponder group (2,465.36 +/- A 3,293.24 pg/mL) than in the responder group (942.38 +/- A 1,293.48 pg/mL) (p < 0.05). The optimal sensitivity and specificity cutoff point for predicted nonresponders was 1,093.00 pg/mL or higher. The sensitivity and specificity for prediction of IVIG response were respectively 70.0 and 76.5 %. The findings show that NT-proBNP is a helpful marker in determining patients at risk for not responding selleck products to initial IVIG treatment. The authors suggest that patients with an NT-proBNP level of 1,093.00 pg/dL or higher are likely to fail initial IVIG and may require further rescue

“Background: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are widely used in clinical practice. The safety and efficacy of these agents in peritoneal dialysis (PD) patients are unclear.

Objectives: We conducted a systematic review to study the safety and efficacy of ACEI and ARB use in PD patients. Primary outcome measures were mortality and cardiovascular (CV) events; secondary outcome measures were renal function, proteinuria, hyperkalemia, and erythropoietin requirement at 3 months.

Methods: We searched Medline, EMBASE, Cochrane Central Register of

Controlled Trials, trial registry Web sites, reference lists of eligible and review articles, as well PP2 research buy as abstracts from the American Society of Nephrology and Canadian Society of Nephrology meetings. To be eligible, studies had to be randomized controlled trials that allocated PD patients to ACEI and ARB use BTSA1 or to placebo or other antihypertensive medications, included adult patients, and reported on at least one of the outcome measures.


418 citations were identified. Four met the eligibility criteria. Three examined CV events and mortality, of which two studies did not have any events. The third showed no statistically significant difference between control and treatment groups in either CV events or mortality: odds ratio 1.56 [95% confidence interval (CI) 0.24 - 10.05] for mortality and odds ratio 1.00 (95% CI 0.19 – 5.40) for CV events. Two studies reported renal function at 12 months and the weighted mean difference was 0.91 mL/minute/1.73 m(2) (95% CI 0.14 – 1.68), favoring ACEI and ARB use.

Conclusions: In PD patients, evidence for the use of ACEIs and ARBs for reduction of mortality and CV events is lacking. Limited data suggest that they slow the loss of residual renal function.”
“Background: Soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) is an activating receptor on inflammatory cells upregulated by microbial products. Elevated levels of sTREM-1 have been associated with the diagnosis and prognosis of patients with sepsis, severe pneumonia and chronic obstructive pulmonary disease (COPD).

Methods: The course of infection was assessed by scintigraphy wit

Methods: The course of infection was assessed by scintigraphy with (99m)Technetium-abelled leucocytes, Duplex-Doppler ultrasound, angio-computed tomography Cyclopamine nmr (CT) and microbiological examination.

Results: The mean follow-up was 22.8 (+/- 10.1) months. There was a significant decrease in leucocyte accumulation around the graft among all groups (group 1: p = 0.012, group 2: p = 0.006 and group 3: p = 0.021). The postoperative mortality rate in groups 1,2 and 3 was 8%, 23% and 11%, respectively. The postoperative morbidity was 35% in group 2, 16%

in group 1 and 7% in group 3.

Conclusion: Our study suggests that silver-coated prostheses can be as effective as arterial allografts in the treatment of infections of vascular prostheses. (C) 2010 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.”
“Background: Little is known about the threshold level of low-density lipoprotein cholesterol (LDL-C) for statin therapy in acute myocardial infarction (AMI).

Hypothesis: The aim of this study was to investigate the short-term benefit of the statin in post-MI patients with low LDL-C levels.

Methods: Between November 2005 and January 2008, 6866 statin-naive patients were selected from the Korea AMI registry. Major adverse cardiac event (MACE) was defined as a composite of death, recurrent MI,

and revascularizations.

Results: The 6-month 5-Fluoracil supplier MACE and mortality showed a U-shaped curve, with the lowest rate

at 114-122 mg/ dL. Propensity scores for statin use were calculated for patients with LDL-C <= 113 mg/ dL, and they were used to match the patients who received statin (statin user, n = 1031) with those who did not receive it (statin nonuser, n = 1031). The 6-month MACE was not significantly different between statin users and statin nonusers (9.4% vs 11.0%; hazard ratio [HR]: 0.847, 95% confidence interval [CI]: check details 0.646-1.111, P = 0.230), whereas the 6-month mortality was significantly lower in statin users (7.2% vs 9.7%; HR: 0.728, 95% CI: 0.539-0.984, P = 0.039). However, when the analyses were repeated in the patients with LDL-C <= 105 mg/ dL, not only the 6-month MACE (9.5% vs 9.9%; HR: 0.945, 95% CI: 0.700-1.277, P = 0.713) but also the 6-month mortality (7.0% vs 8.7%; HR: 0.793, 95% CI: 0.566-1.111, P = 0.177) was not significantly different between statin users and statin nonusers (n = 876 in each group).

Conclusions: The beneficial effects of statin therapy seem to vanish when LDL-C is below a certain level in AMI patients.”
“Syncope is a transient and abrupt loss of consciousness with complete return to preexisting neurologic function. It is classified as neurally mediated (i.e., carotid sinus hypersensitivity, situational, or vasovagal), cardiac, orthostatic, or neurogenic.

Erect penile length consequent to IPP implantation was measured a

Erect penile length consequent to IPP implantation was measured at 6 weeks, 6 months and at 1 year after surgery. The Sexual Health Inventory for Men (SHIM) was administered before, and at 6 months and 1 year after IPP implantation. Erect Selleck Bafilomycin A1 penile length (mean +/- s.e.) as induced by ICI was 13.2 +/- 0.4 cm, whereas the lengths attained with IPP were 12.4 +/- 0.3, 12.5 +/- 0.3 and 12.5 +/- 0.4 cm at the sixth week, sixth month and 1-year follow-ups, respectively. There were 0.83 +/- 0.25, 0.75 +/- 0.20 and 0.74 +/- 0.15 cm decreases in erect penile length at

6 weeks, 6 months and 1 year, respectively, after IPP implantation when compared with that after ICI (P < 0.05). The SHIM scores for patients C59 wnt reporting shorter penises were the same as those for patients without complaints at the 6-month and 1-year follow-ups (P > 0.05). To our knowledge, this is the first study to objectively show a significant decrease in erect penile length after IPP implantation when compared

with that after ICI. However, this decrease did not affect the effectiveness of IPP in treating ED.”
“Not only is there limited information in the literature regarding the beta-carotene (BC) isomer profile of micelles from digested foods; few studies have looked at their subsequent uptake and transport by human intestinal Caco-2 cells. Therefore, the aims of the present study were, first, to assess the profile of BC isomers in micelles from digested raw and cooked carrots; and, second, to determine their cellular uptake and transport. Greater amounts of all-trans-, 13-cis- and 15-cis-BC isomers were present in the micelles of selleck products cooked carrots compared with raw carrots. Furthermore, micelle fractions obtained from the most highly processed (pureed) carrots had greater (P < 0.05) amounts of all-trans-, 13-cis- and 15-cis-BC compared with those derived from raw and boiled carrots. A similar trend was seen with BC isomer uptake and transport. Our data suggest that the food matrix and degree of processing play important

roles on carotenoid isomerization and bioavailability. (C) 2010 Elsevier Ltd. All rights reserved.”
“Aims and Methods: The purpose of this study was twofold: (1) to determine the characteristics of escape rhythms at predefined serial time intervals following AV node ablation and pacemaker implantation, and (2) to identify risk factors predictive of unstable escape rhythms. Patients undergoing AV node ablation and pacemaker implantation were assessed for the presence or absence of an escape rhythm during pacemaker interrogation at five predetermined serial time points. Baseline demographics and comorbid conditions were evaluated as potential predictors of those with labile escape rhythms.

Results: Seventy-nine percent of the 96 patients studied had an underlying escape rhythm (>= 30 beats per minute) immediately postablation.

Method: We performed an analytical comparative cross-sectional st

Method: We performed an analytical comparative cross-sectional study. We studied 20 right-handed children with DD and 20 healthy right-handed control subjects (CS). Children in both groups were age, gender, and school-grade matched. Focusing on the right hemisphere’s contribution, we utilized tests to measure alterations in central auditory processing (CAP), such as determination of

frequency patterns; sound duration; music pitch recognition; and identification of environmental sounds. We compared results among the two groups. selleck chemical Results: Children with DD showed lower performance than CS in all CAP subtests, including those that preferentially engaged the cerebral right hemisphere. Conclusion: Our data suggests a significant contribution of the right hemisphere in alterations of CAP in children with DD.Thus, right hemisphere CAP must be considered for examination and rehabilitation of children with DD.”
“Premature closure or restriction

of foramen ovale (FO) is a rare but known entity. FO diameter < 2 mm and Doppler velocity > 120 cm/s, diameter < 3 mm with Doppler velocity measured gradient > 5 mmHg have all being used by various authors to describe this entity. Some neonates with restrictive FO have been noted to have severe pulmonary hypertension with no clinical signs or symptoms and with spontaneous resolution without any intervention. Seven consecutive neonates were indentified in the database between HSP990 mw 01/01/2003 and 06/30/2010 with diagnosis of restrictive PFO (diameter < 2 mm) with structurally normal heart and their initial and follow-up echocardiogram as well as hospital medical records were reviewed. As a control, seven neonates with diagnosis of

pulmonary hypertension and respiratory distress syndrome or meconium aspiration Selleck AZD4547 syndrome were randomly selected. Eighty-six percent of the patients in the control group were symptomatic and required treatment as compared to 14% in the restrictive FO group (p = 0.03). Further, the fall in the peak instantaneous pulmonary artery pressure on follow-up echocardiogram was greater in the restrictive FO group compared with the non-restrictive group (p = 0.03). Patients with pulmonary hypertension and a restrictive FO with no other associated congenital heart disease and/or lung pathology behave differently when compared to neonates with non-restrictive FO and pulmonary hypertension with associated lung disease. They seldom manifest symptoms requiring intervention and tend to show a faster drop in their pulmonary artery pressure toward the normal.”
“OBJECTIVES: The aim of this study was to investigate the protective effects of aqueous extracts of roselle (Hibiscus sabdariffa L. UKMR-2) against red blood cell (RBC) membrane oxidative stress in rats with streptozotocin-induced diabetes.

Subject Before regional anesthesia, the patient suffered from a

Subject. Before regional anesthesia, the patient suffered from a phantom hand that cramped and was immovable.

Setting. We performed a diagnostic axillary blockade of the brachial plexus to differentiate peripheral from more central contributions to phantom limb pain.

Results. During blockade of the brachial plexus, the patient reported a reduction of phantom limb pain for the first time following years of suffering and a complete loss of cramping together with muscle relaxation of the phantom hand. Additionally,

BIX 01294 clinical trial we found cortical reorganization in the primary somatosensory cortex (re-reorganization). Strikingly, the relaxed phantom limb together with the reduction of phantom limb pain remained preserved even 6 months after blockade of the brachial plexus.

Conclusions. A single temporary blockade of the brachial CX-6258 ic50 plexus may relieve phantom limb pain and unpleasant phantom feelings (cramping) for an extended period.”
“OBJECTIVES: To estimate whether training on previously validated laparoscopic skill stations translates into improved technical performance in the operating room.

METHODS: We performed a multicenter, randomized, controlled trial evaluating the performance of a laparoscopic bilateral midsegment salpingectomy. Residents were randomized to either traditional teaching (no simulation)

or faculty-directed sessions in a simulation laboratory. A sample size of at least 44 lower-level residents (postgraduate year find more [ PGY] 1 or 2) and 66 upper-level

(PGY 3 or 4) were necessary to demonstrate a 50% improvement in performance assuming an a error of 0.05 and beta error of 0.20 for each group independently. The primary outcomes were the final total normalized simulation score and the operating room performance score. Paired t test and Wilcoxon rank-sum tests were used to evaluate the differences within and between cohorts. Our final model involved a multiple linear regression analysis for the main effects of a priori-specified variables.

RESULTS: We enrolled 116 residents from eight centers across the United States. There was no statistically significant difference in baseline simulation or operative performances. Although both groups demonstrated improvement with time, the trained group improved significantly higher normalized simulation scores (378 +/- 54 compared with 264 +/- 86; P<.01) and higher levels of competence on the simulated tasks (96.2% compared with 61.1%; P<.01). The simulation group also had higher objective structured assessment of technical skills scores in the operating room (27.5 compared with 30.0; P=.03).

CONCLUSION: We found that proficiency-based simulation offers additional benefit to traditional education for all levels of residents. The use of easily accessible, low-fidelity tasks should be incorporated into formal laparoscopic training.”

We simulate the performance of our

experimental devices u

We simulate the performance of our

experimental devices using the COMSOL platform, examine the eigenfrequencies of the structure, and find a hybrid mode which is trapped both vertically and laterally in the ZnO film. Calculating the effective velocity of the simulated modes, we find the simulated effective velocities to be within 1.5% of our measured results. Finally, we compare simulation results to experimentally measured results of a previously observed hybrid mode and achieve a 0.2% Selleck YM155 agreement. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3517097]“
“The solubility, electrical conductivity, and other properties of polyaniline (PANI) are highly dependent on its oxidation state. In this work, polyaniline (PANI1) prepared by peroxodisulphate induced polymerization of aniline in acidic aqueous medium in presence of benzenediazonium chloride salt was found to exist in lower

oxidation state than emeraldine form of PANI and was highly soluble in common organic solvents. This polymer was subjected to positron annihilation spectroscopic study to investigate the correlation between the oxidation state of the polymer and defect sites generated Acalabrutinib by different degrees of protonation that in turn affect its electrical conductivity. The positron annihilation lifetime data were resolved to yield a three-component fit for PANI1 subjected to different levels of protonation. The variation of positron annihilation parameters (tau(1), I-2) and Doppler broadening parameters (R, S) as a function of protonation level of the polymer indicate the dopant sites increase initially on protonation and reach a saturation value after a certain level of acidification. The lower value of electrical conductivity and the intensity of intermediate lifetime component (I-2) for PANI1 compared to PANI in emeraldine oxidation state indicate the presence of lesser number of quinoid-imine moieties that could undergo protonation

and thus yield highly enriched trapping centers. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 119: 2554-2559, 2011″
“Many patients suffer recurrent episodes of temporomandibular joint (TMJ) dislocation due to an excess of selleck products muscle contraction or spasticity in the depressor muscles of the jaw. The manual repositioning using the Nelaton maneuver is the first treatment. Occasionally, it may be necessary to use sedation or general anesthesia to achieve the desired muscle relaxation. In case of recurrence, surgical treatment is indicated. One nonsurgical method of treatment is the local infiltration of botulinum toxin type A. We present 4 cases of recurrent TMJ dislocation in patients suffering from conditions of neurologic origin, with considerable motor deterioration, treated with local infiltration of botulinum toxin type A.

Conclusions: It is feasible to use the wall between the aorta and

Conclusions: It is feasible to use the wall between the aorta and left atrium as an access route for a potentially entirely percutaneous LVAD. Such a system obviates the need for accessing the left ventricle, minimizing complications. In the future, such devices may allow widespread treatment of heart failure, malignant cardiac arrhythmia, and severe aortic and mitral valvular disease. (J Cardiac Fail 2011;17:511-518)”
“Salvia species have been mainly studied for essential oils; among them Salvia tomentosa Mill. has been commonly used for various activities. Finding novel formulations for application of essential oils has

been a concern of the field. In this study, organogels of essential oil of Salvia tomentosa have been investigated LY2603618 concentration with a novel preparation method. The uniformity, antibacterial, antifungal activity and antioxidant properties of Salvia tomentosa essential oil and its organogel formulation were evaluated. According to the results, it can be stated that formulation in C974 organogels was successfully prepared very fast with PEG 400 under microwave irradiation. The NMR and GC/MS studies confirmed the unchanged structure of essential oil. TEAC and antimicrobial activity studies Trk receptor inhibitor showed the efficiency in the organogels. Formulation prepared can be used for antimicrobial and antioxidant purposes in topical drug delivery. The suggested method is suitable for scale-up and a process like that should be time and energy

“We report on the fabrication and tunneling characteristics of pulsed-laser deposited LaSrMnO (LSMO)/PbZrTiO(PZT)/LSMO/SrTiO(3) multilayers, using PZT layer as a tunnel barrier. The trilayer films show magnetic onset at about 360 K with ferromagnetic hysteresis at room temperature. The microscopic studies show that the effective barrier thickness is reduced due to the presence of defects in the barrier region. this website Our results suggest that the asymmetric

deformation of the barrier potential profile induced by the ferroelectric polarization of PZT influences the tunneling characteristics and can be used for electrically controlled readout in quantum-computing schemes. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3054380]“
“Background: Studies have shown that the autonomic dysfunction accompanied by impaired baroreflex sensitivity was associated with higher mortality. However, the influence of decreased baroreflex sensitivity on cardiac function, especially in diastolic function, is not well understood. This study evaluated the morpho-functional changes associated with baroreflex impairment induced by chronic sinoaortic denervation (SAD).

Methods and Results: Animals were divided into sinoaortic denervation (SAD) and control (C) groups. Baroreflex sensitivity was evaluated by tachycardic and bradycardic responses, induced by vasoactive drugs. Cardiac function was studied by echocardiography and by left ventricle (LV) catheterization.