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contributions GAV conceived of the study, done the statistical
analysis and wrote the manuscript. GBM collected the RCTs and patient’s clinical data. ECF, LIF, SLA and EJS participated in the design of the study and helped write the paper. Wortmannin manufacturer All authors read and approved the final manuscript.”
“Erratum to: Med Chem Res DOI 10.1007/s00044-014-1213-8 In the original version of this paper, two author’s names were incorrectly published. The correct names of the authors are Khalid Mohammed Khan and Sammer Yousuf.”
“Introduction Phenothiazines are an important class of drugs exhibiting antipsychotic, antihistaminic, antitussive, and anti-emetic activities (Gupta and Kumar, 1988). The most significant selleck products modifications of the phenothiazine structure are the introduction of new pharmacophoric substituents at the thiazine nitrogen atom and the substitution of the benzene rings with other homoaromatic or heteroaromatic ones. Recently studied phenothiazines exhibit promising antibacterial, antifungal, anticancer, antiviral,
anti-inflammatory, antimalarial, antifilarial, trypanocidal, anticonvulsant, analgesic, immunosuppressive, and multidrug resistance reversal properties (Aaron et al., 2009; Dasgupta et al., 2008; Motohashi et al., 2006; Pluta et al., 2011). In our study of new azaphenothiazines, we elaborated the synthesis of new types of phenothiazines containing the heterocyclic rings of pyridine or quinoline. Some of those azaphenothiazines exhibited promising immunosuppressive and anticancer activities against cell lines Fossariinae of ten types of human cancer in vitro: leukemia, non-small cell lung cancer, melanoma, as well as colon, CNS, ovarian, renal, prostate, breast, and skin cancer (Jeleń et al., 2013; Pluta et al., 2010; Zimecki et al., 2009). Free radicals, generated in many redox processes, may induce oxidative damage of proteins, lipids, and DNA. They affect living cells and mediate the pathogenesis of many chronic diseases, such as atherosclerosis, Parkinson’s and Alzheimer’s diseases, stroke, and arthritis, acting by various mechanisms.