The timeframe was shorter at 3–9 months (median 6 months). Discordant responders, whether virological or immunological, were at
an increased risk of all-cause and nonaccidental mortality over a 5-year period. In another small cohort of 51 treatment-naïve patients followed for 48 weeks , a discordant response was defined as a CD4 increase of <50 cells/mL with a viral load decrease of >1 log10 copies/mL or to <200 copies/mL. At 48 weeks, 15.7% of patients had a discordant response, but all experienced a CD4 increase of >50 cells/μL by 2 years of follow-up. Of those patients in the Swiss Cohort who maintained a viral load <1000 copies/mL throughout a 5-year period after starting HAART, 35.8% had an incomplete immunological Rucaparib research buy response, defined as a CD4 count of <500 cells/μL . A smaller CD4 cell count increase, as early as 3–6 months, was a predictor of an incomplete response. In UK CHIC, a
discordant response was associated with a higher baseline CD4 cell count. If treatment is started at higher CD4 cell counts then scope for a further rise may be limited, but given the low baseline count (median 170 cells/μL), this is unlikely. In the Swiss Cohort study, with similar CD4 counts at baseline (median 180 cells/μL), an incomplete response was associated with a lower baseline CD4 count and more advanced disease. Other studies, however, have reported similar findings to ours, with higher pre-therapy CD4 cell BTK inhibitor library counts being associated with smaller gains in CD4 cell count 2 to 4 years later [13,17]. In common with other studies, a discordant or incomplete immune response was associated with older age [9,17]. In the EuroSIDA study, reduced recovery of CD4 cell counts was related to older age, independent of virological response . As reported elsewhere, a discordant response was associated with a lower baseline viral load [4,12]. Because only those with a viral load <50 copies/mL within 6 months were selected, those
with a higher baseline viral load would need to have had a particularly rapid response, which may select also for those more likely to experience a rapid rise in CD4 cell count. We did not find a difference in response according to the type of regimen. A high next proportion of patients initiated an NNRTI-based combination, which reflects more recent clinical practice, and is linked to our restricting the analysis to only those patients tested with an HIV viral load assay with a threshold of 50 copies/mL. Individual drug combinations were not analysed. A reduced risk of a discordant response has been reported with protease inhibitor-containing regimens . In the absence of a prospective study this may also reflect a calendar time effect as treatment practice has evolved. In UK CHIC, the number of new AIDS events or deaths in either group was small but the data suggest that those with a discordant response have a less favourable outcome.