Observer: C. Perronne. Clinical research group: V. Le Moing, Selleckchem Small molecule library C. Lewden. Data monitoring and statistical analysis: J. Biemar, S. Boucherit, A. D. Bouhnik, C. Brunet-François, M. P. Carrieri,
F. Couturier, J. L. Ecobichon, V. Guiyedi, P. Kurkdji, S. Martiren, M. Préau, C. Protopopescu, C. Roy, J. Surzyn, A. Taieb, V. Villes, C. Wallet. Promotion: Agence Nationale de Recherches sur le Sida et les hépatites virales (ANRS, Action Coordonnée no. 7). Other support: Collège des Universitaires de Maladies Infectieuses et Tropicales (CMIT ex APPIT), Sidaction Ensemble contre le Sida, and Abbott, Boehringer-Ingelheim, Bristol-Myers Squibb, GlaxoSmithKline, Gilead Sciences, Pfizer and Roche. Clinical centres (co-ordinators): this website Amiens (Prof. J. L. Schmit), Angers (Dr J. M. Chennebault), Belfort (Dr J. P. Faller), Besançon (Prof. J. L. Dupond, Dr J. M. Estavoyer, Dr M. C. Drobachef), Bobigny (Prof. O. Bouchaud), Bordeaux (Prof. M. Dupon, Prof. Longy-Boursier, Prof. P. Morlat, Prof. J. M. Ragnaud), Bourg-en-Bresse (Dr P. Granier), Brest (Prof. M. Garré), Caen (Prof. R. Verdon), Compiègne (Dr D. Merrien), Corbeil Essonnes (Dr A. Devidas), Créteil (Prof. A. Sobel), Dijon
(Prof. H. Portier), Garches (Prof. C. Perronne), Lagny (Dr P. Lagarde), Libourne (Dr J. Ceccaldi), Lyon (Prof. D. Peyramond), Meaux (Dr C. Allard), Montpellier (Prof. J. Reynes), Nancy (Prof. T. May), Nantes (Prof. F. Raffi), Nice (Prof. J. G. Fuzibet, Prof. P. Dellamonica), Orléans (Dr P. Arsac), Paris (Prof. E. Bouvet, Prof. F. Bricaire, Prof. P. Bergmann, Prof. J. Cabane, Dr J. Monsonego, Prof. P. M. Girard, Prof. L. Guillevin, Prof. S. Herson, Prof.
C. Leport, Prof. M. C. Meyohas, Prof. J. M. Molina, Prof. G. Pialoux, Prof. D. Salmon), Poitiers (Prof. B. Becq-Giraudon), Reims (Prof. R. Jaussaud), Rennes (Prof. C. Michelet), Saint-Etienne (Prof. F. Lucht), Saint-Mandé (Prof. T. Debord), Strasbourg (Prof. J. M. Lang), Toulon (Dr J. P. De Jaureguiberry), Toulouse (Prof. B. Marchou), Tours (Prof. J. M. Besnier). “
“In long-term HIV-infected patients, peripheral lipoatrophy (LA) and central lipohypertrophy (LH) appear to be related to the same insults (virus and antiretroviral Niclosamide drugs), but are likely to be associated with different fat depot physiologies. The objective of this study was to describe the natural history of lipodystrophy assessed using dual energy X-ray absorptiometry (DEXA) and computed tomography (CT) in a large HIV out-patients metabolic clinic. An observational retrospective study was carried out including HIV-infected patients recruited at the Metabolic Clinic of Modena, Modena, Italy, who were assessed for lipodystrophy and had at least two anthropometric evaluations using DEXA for leg fat per cent mass and abdominal CT for visceral adipose tissue (VAT). Factors associated with leg fat per cent and VAT changes were analysed using multivariable generalized estimating equation (GEE) regression models.