Bupropion SR was well tolerated, Src Bosutinib however. In addition, relapse to alcohol or drug use during smoking cessation occurred in a small minority of participants and was similar to the rate found in a prior study of recovering alcoholic smokers treated for tobacco dependence (Martin et al., 1997). Additional research in smokers with a history of alcohol dependence is warranted to determine the most effective pharmacological and behavioral approaches to treatment for these smokers who are at high risk of tobacco-caused morbidity and mortality. Funding Funding was provided by National Institute on Alcohol Abuse and Alcoholism grant AA11219. Declaration of Interests None declared. Supplementary Material [Article Summary] Click here to view. Acknowledgments The authors thank Julie K.

Richardson for her technical assistance in preparation of this manuscript.
Research has demonstrated consistently that smokers score higher on personality scales measuring a tendency to experience negative emotions and lower on scales indicative of the ability to constrain behavior. Over a decade ago, a major review concluded that smokers, compared with nonsmokers, were more likely to be high in traits such as depression, anxiety, anger, social alienation, impulsivity, sensation seeking, and psychoticism and low in traits such as conscientiousness and agreeableness (Gilbert & Gilbert, 1995).

More recent reports demonstrated a link between smoking and higher neuroticism, extraversion, hostility, aggression, novelty seeking, impulsiveness, excitement seeking, and sensation seeking and lower agreeableness, conscientiousness, self-discipline, and constraint (Calhoun, Bosworth, Siegler, & Bastian, 2001; Etter, Pelissolo, Pomerleau, & De Saint-Hilaire, 2003; Kubicka, Matejcek, Drug_discovery Dytrych, & Roth, 2001; Munaf�� & Black, 2007; Munaf��, Zetteler, & Clark, 2007; Terracciano & Costa, 2004; Vollrath & Torgersen, 2008; Whiteman, Fowkes, Deary, & Lee, 1997) with neuroticism demonstrating a consistent relationship with tobacco dependence (Breslau, Kilbey, & Andreski, 1993; Kawakami, Takai, Takatsuka, & Shimizu, 2000; Kendler et al., 1999; McChargue, Cohen, & Cook, 2004). Although significant smoking�Cpersonality associations have been demonstrated in a range of studies, these studies generally have not assessed a history of psychiatric disorders, with a few notable exceptions (Breslau et al., 1993; Degenhardt & Hall, 2001; Kendler et al., 1999), and no studies have sought explicitly to provide a comprehensive examination of the overlap and interactions between personality and psychiatric disorders as they relate to smoking. This is an important omission.