4% as a person who had had (or has) cancer, 1.4% as a cancer patient and 1.2% as a cancer victim. People who were older and who
reported higher personal growth after diagnosis were more likely check details to assume a survivor identity at 5?years. At 5?years, survivors had higher benefit finding and better satisfaction with life. Cancer survivors uniquely reported a significant decrease in somatization and acceptance, and increases in satisfaction with life and physical activity over time. Conclusions For patients with colorectal cancer, the cancer survivor identity is common but not universal 5?years after diagnosis; and may evolve from looking for benefit after cancer through personal growth. People who adopt a cancer survivor identity report more positive adjustment outcomes after cancer and this has implications for the design of clinical and community support interventions. Copyright (c) 2011 John Wiley & Sons, Ltd.”
“Aim: To examine the demographic characteristics,
circumstances, RAD001 mouse toxicology and major organ pathology of MDMA-related deaths in Australia.
Methods: Retrospective review of cases in which MDMA was a cause of death, as identified from the National Coronial Information System.
Results: 82 cases over a 5-year period were identified. The majority of decedents were male (83%), with a median age of 26 years. Deaths were predominantly due to drug toxicity (82%), with MDMA the sole drug causing death in 23% of cases, and combined drug toxicity in 59% of cases. The remaining deaths (18%) were primarily due to pathological events/disease or injury, with MDMA a significant contributing condition. Cardiovascular pathology, typically atherosclerosis, was detected in 58% of decedents, with moderate-severe Silmitasertib datasheet atherosclerosis in 23% of cases. The prevalence of such pathology is higher than
that expected among similarly aged members of the general Population. Cerebrovascular pathology, primarily cerebral haemorrhage and hypoxic damage, was present in 12% of cases.
Conclusions: MDMA has contributed to a clinically significant number of deaths in Australia. The prevalence of cardiovascular pathology was similar to that among methamphetamine and cocaine fatalities. Whilst cardiovascular pathology may reflect the use of other stimulants, the cardiotoxic properties of MDMA have been well-documented. Future studies examining MDMA-related morbidity and mortality in the context of other risk factors are recommended. Overall, the current study highlights the need to educate users about the potential harms of MDMA use, particularly that in conjunction with other Stimulants, opioids and alcohol, which are known to increase overall toxicity. (C) 2009 Elsevier Ireland Ltd. All rights reserved.”
“The epidemic of obesity and Type 2 diabetes has driven the need for novel and efficacious treatments.