TSB was measured using Pars Azmun Company biochemistry kits. Phototherapy was performed using five special blue lamps with wavelengths 420-450 nanometers (Tusan Company, Tehran-Iran). The independent samples t-test was employed for the comparison of bilirubin and the other parameters in the study. The data were analyzed with SPSS software (version 17). P values less than
0.05 were considered statistically significant. There was no significant difference in mean total bilirubin at baseline Inhibitors,research,lifescience,medical between the groups (P>0.05). There was a significant reduction in mean total bilirubin 12, 24, 36, and 48 hours after treatment in intervention groups I and II by comparison with the control group (P<0.001). However, there was no statistically significant difference between mean total bilirubin 12, 24, 36, Inhibitors,research,lifescience,medical and 48 hours after treatment between intervention group I and intervention group II (P<0.001). In this study, the neonates neither experienced any kind of adverse effect of Clofibrate nor needed exchange transfusion. Our findings in the present study are consistent Inhibitors,research,lifescience,medical with the results of other studies that have demonstrated the efficacy of Clofibrate in decreasing indirect hyperbilirubinemia and have also revealed that lower doses of Clofibrate can be used with
the same therapeutic efficacy in reducing TSB levels in term infants with non-hemolytic Inhibitors,research,lifescience,medical hyperbilirubinemia.3-6 Lower, rather than higher, doses of Clofibrate can, therefore, be used to decrease TSB levels with lower side effects in healthy term neonates. In combination with phototherapy, Clofibrate (irrespective of its dosage) can reduce TSB levels in neonates with non-hemolytic indirect hyperbilirubinemia without adverse effects. A single dose of 25 mg/kg Clofibrate Inhibitors,research,lifescience,medical in the treatment of neonatal hyperbilirubinemia is effective and safe. Conflict of Interest: None declared.
A 13-year-old boy was brought to the Emergency Department of Nemazee Hospital, Shiraz, Iran, at 10:00 p.m., June 1st, 2012, following
a collision between his bicycle and a motorcycle, during which the patient had the left side of his abdomen injured by his bicycle handlebar. On admission, the patient only complained of left flank pain. A review of his surgical also history was remarkable for two previous surgical operations; i.e. tonsillectomy and right inguinal herniorrhaphy. He did not mention any abdominal discomfort of recent duration. On arrival, he was thoroughly conscious, was not tachypneic, and had an axillary temperature of 37°C, blood pressure of 110/70 mm Hg, and heart rate of 90 bpm with no orthostatic change. Mild ecchymosis of his periumbilical area and left flank was visible. The bowel sounds were normally audible. Abdominal buy HKI-272 palpation revealed mild to moderate tenderness in the same ecchymotic areas. A complete blood count (CBC) yielded a hemoglobin count of 13.