This led to the formulation of a diagnostic category

called Gross Stress Reaction, which appeared in the first Diagnostic and Statistical Manual (DSM-I), published in 1952. Its description emphasized that the disorder was a reaction to a great or unusual stressor that invoked overwhelming fear in a normal personality. It emphasized that the disorder was transient and reversible; if the symptoms persisted, another diagnosis was to be given. Thus the definition was more influenced by the psychodynamic traditions that prevailed at the time than by biological models, and it did not lend itself to making frequent diagnoses of service-connected disabilities in the post-World Inhibitors,research,lifescience,medical War II era. Thereafter the diagnosis went into oblivion. Since it was closely linked to the history of warfare, it was completely omitted from DSM-II, published in 1968―23 years after the last Great War

and during a period of relative peace. When the DSM-III Task Force was assembled in the early 1970s, one of the tasks that it confronted was to decide Inhibitors,research,lifescience,medical whether the diagnosis of Gross Inhibitors,research,lifescience,medical Stress Reaction should be reinstated in the DSM nosological system. The Vietnam War was winding down and had been very unpopular. Unfortunately, the general public was not able to distinguish between the war and the people that our country had drafted to fight in it, and so Vietnam veterans quite understandably felt defensive, undervalued, and angry. A small but militant subgroup of Vietnam veterans clamored Inhibitors,research,lifescience,medical for the introduction of a diagnosis that would recognize

the potential consequences of experiencing the stress of combat, and that might perhaps provide disability and treatment benefits for the psychiatric disorder that combat stress induced. Bob Spitzer, the Task Force chair, asked me to deal with the problem; he knew that I was hard-working Inhibitors,research,lifescience,medical and intellectually agile; but he did not know that I was actually already an expert on the topic of stress-induced neuropsychiatric disorders. I began my psychiatry career by studying the physical and mental consequences of one of SB-3CT the most horrible stresses that human beings can experience: suffering severe burn Topoisomerase inhibitor injuries. Within this model of stress, I had already examined brain abnormalities using electroencephalography, the pattern of acute and chronic symptoms, the long-term outcome and its predictors, and the role of coping mechanisms.12-16 I was also well aware of the extensive research that had been done to Identify symptom patterns that arise as a consequence of exposure to a wide variety of stressors, ranging from natural disasters to death camps to military combat. The answer to the veterans’ request was obvious to me: there is a well-established syndrome, defined by a characteristic set of physiological (autonomic) and cognitive and emotional symptoms, that occurs after exposure to severe physical and emotional stress.