Some studies have suggested the exchange reaction needs Fc identification of erythrocyte bound buildings by fixed tissue macrophages, adopted by proteolysis of CR1. Still other studies have suggested that the transfer of soluble immune complexes from erythrocytes to monocytes is driven by the greater number of immune complex binding order Fingolimod sites available on monocytes relative to erythrocytes and that the transfer effect is not dependent on factor I or other enzymatic processing of immune complexes. Our research showed that CR3 represents significant role in this process while Fc R is additional and that both CR3 and Fc RIII/II take part in the transfer reaction of type 3 pneumococci. These results are in line with the results of Hepburn et al. To the transfer reaction of soluble immune complexes, though in their study the transfer reaction was considered as a series of responses. The difficulty of pneumococcal surface parts will make the exchange effect of pneumococci harder than in case of soluble immune complexes. Pneumococci have now been demonstrated to interact with several macrophage Chromoblastomycosis receptors apart from complement and Hamilton academical receptors, such as Toll like receptors 2 and 4, scavenger receptor SR AI/II, and SIGN R1, which may participate in the shift reaction also. In conclusion, the present study demonstrates the kind 3 capsule of pneumococci inhibits C3 deposit through the choice pathway. But, while in the presence of anti capsule antibody, the deposition of C3, C1q, and C4 through the classical pathway is increased, which promotes the exchange of pneumococci and the IA of pneumococci from erythrocytes to macrophages. Moreover, we found that CR3 represents an important role in mediating the transfer effect and that Hamilton academical RIII/II is supplemental. Demonstrating a position for IA within the in vivo clearance of pneumococci is a difficult problem. ubiquitin conjugation We are hopeful, but, that we will have the ability to address these dilemmas in the foreseeable future by reports that will include evaluations of immune body approval between transgenic mice expressing human CR 1 on their erythrocytes and wild type mice which absence CR 1 expression on their erythrocytes. of pneumococci and the transfer of pneumococci from erythrocytes to macrophages are dependent on deposition onto the surface, indicating that elements that boost C3 deposition on the pneumococcal surface might enhance both the IA and the transfer result of pneumococci. In our study, we have found that antibody to form 3 pneumococcal capsular polysaccharide encourages the IA of pneumococci by increasing match C3b, C1q, and C4b deposit, and the increased erythrocyte destined pneumococci could possibly be transferred to macrophages through interaction with CR3 and Fc RIII/II of macrophages.