Results: A total of 471 patients was randomized. No significant improvements in MADRS total score were observed at week eight (last observation carried GW4869 mouse forward) with either active treatment (quetiapine XR, -17.21 [P=0.174]; escitalopram,
-16.73 [P=0.346]) versus placebo (-15.61). There were no significant differences in secondary end points versus placebo, with the exception of week-eight change in PSQI global score (quetiapine XR, -4.96 [P<0.01] versus placebo, -3.37). Mixed-model repeated-measures analysis of observed-case data suggested that the primary analysis may not be robust. Most commonly reported adverse events included dry mouth, somnolence, and dizziness for quetiapine XR, and headache and nausea for escitalopram.
Conclusion: In this study, neither quetiapine XR (150/300 mg/day) nor escitalopram (10/20 mg/day) showed significant separation from placebo. Both compounds have been shown previously to be effective in the treatment of MDD; possible reasons for this failed study are discussed. Quetiapine XR was generally well tolerated, with a profile similar to that reported previously.”
“Study Design. A prospective study on predictive factors for the outcome of 164 patients with adult isthmic spondylolisthesis operated on with fusion.
Objective. In view of the need
to better select patients Caspase cleavage for fusion, we investigated the use of the pain drawing (PD) and other potential factors for predicting the outcome of fusion.
Summary of Background Data. Results on predictive factors of outcome after spinal fusion have been contradictory and large, well-defined, patient samples with adequate observation times are lacking.
Methods. Questionnaires including possible predictive factors and PDs were obtained before surgery. Degree and level of slip were
documented. Outcome was quantified selleck screening library by measurement of pain (VAS), Disability Rating Index, the Oswestry Disability Index, and global assessment by the patient into “”much better,”" better,”" “”unchanged,”" or “”worse. “”The 2-year follow-up rate was 160 of 164 (98%).
Results. In the total sample 49% of patients were much better, 25% better, 14% unchanged, and 12% worse. The following preoperative factors correlated to a worse outcome in the univariate analysis: not working, no regular exercise, female gender, shortness in stature, and a non-organic PD. The multivariate regression analysis showed that work status was the main determinant of outcome. Gender and exercise had less but significant impact (P = 0.004 and 0.02, respectively). In the multivariate regression analysis the PD was not a significant predictor (P = 0.06).
Conclusion. The present study shows that patients working before surgery have a more favorable outcome. Also male gender and regular exercise are indicators of a better outcome after fusion.