Nat Rev Genet 2003, 4:587–597 PubMedCrossRef 28 Liang Y, Hou X,

Nat Rev Genet 2003, 4:587–597.PubMedCrossRef 28. Liang Y, Hou X, Wang Y, Cui Z, Zhang Z, Zhu X, Xia L, Shen X, Cai H, Wang J, Xu D, Zhang E, Zhang H, Wei J, He J, Song Z, Yu XJ, Yu D, Hai R: Genome rearrangements of completely sequenced strains of Yersinia pestis. J Clin PD0325901 chemical structure Microbiol 2010, 48:1619–1623.PubMedCrossRef 29. Jeffreys AJ, Kauppi L, Neumann R: Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex. Nat Genet 2001, 29:217–222.PubMedCrossRef 30. Hacker J, Kaper JB: Pathogenicity islands and the evolution of microbes. Annu Rev Microbiol 2000, 54:641–679.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions

PD and HW carried out genome island analyses. DL contributed to database and data organization. GFG and CC designed the project and editing of the manuscript. YY and CC wrote the final manuscripts. All authors read and approved the final manuscript. The authors declare no conflict of interest.”
“Correction After the publication of this work [1], we became aware of the fact that β-actin control images in Figures two (dotO mutant), three A, eight A and nine A (figures 1, 2, 3 and 4 in this manuscript, respectively) were duplicated.

The last author, Naoki Mori takes full responsibility for these errors in the original article. We repeated the experiments, and all the Figures mentioned above were deleted and new data substituted. The conclusions from the figures are not 8-Bromo-cAMP ic50 altered in any way. We regret any inconvenience that this inaccuracy in the original data might have caused. Figure 1 Figure two – Time course of L. pneumophila -induced IL-8 mRNA expression. Total RNA was extracted from A549 and NCI-H292 cells infected with AA100jm, dotO mutant, Corby or flaA mutant (MOI of 100) for the indicated time intervals and used for RT-PCR. Histograms indicate the relative density data of IL-8 obtained by densitometric analysis of the bands normalized to β-actin. Figure 2 Figure three – L. pneumophila -induced IL-8 mRNA expression in epithelial cells. (A) L. pneumophila infection increases IL-8 mRNA expression in through A549 cells

in a dose-dependent learn more manner. A549 cells were infected with varying concentrations of AA100jm, and the levels of IL-8 mRNA expression were examined by RT-PCR in cells harvested after 8 h. (B) Effect of heat-treatment of L. pneumophila on the ability to induce IL-8 mRNA expression. Expression of IL-8 mRNA in A549 and NCI-H292 cells treated with heat-killed AA100jm was observed at 6 and 24 h after infection. A549 and NCI-H292 cells were infected with the untreated AA100jm at an MOI of 100. β-actin expression served as controls. Representative results of three similar experiments in each panel are shown. Figure 3 Figure eight – NF-κB signal is essential for activation of IL-8 expression by L. pneumophila. (A) Bay 11-7082 and LLnL inhibit IL-8 mRNA expression induced by L. pneumophila.

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