Individuals in these cases can later undergo a recrudescence of virus replication in the central nervous system (CNS) causing a relapse of encephalitis, a process that was first noted in the second fatal case of Hendra virus human infection (O’Sullivan et al., 1997 and Wong Docetaxel in vitro et al., 2009). Quite remarkably, relapsed-encephalitis caused by Nipah virus has been reported in people from several months to as long as 11 years following infection (Abdullah et al., 2012) (reviewed in (Wong, 2010)).

How the henipaviruses survive immune-mediated clearance and can later cause a recrudescence of replication in the CNS is unknown, but this virological feature clearly has important implications for anti-henipavirus therapeutics development. Given the virulence of Hendra and Nipah virus and the increase in their spillover occurrences over the past decade, strategies to mitigate the risk of Hendra and Nipah virus exposure have become paramount. Both Hendra virus and Nipah virus reside in large wild bat populations, which make controlling virus in the reservoir host or influencing the reservoir host population dynamics difficult to impossible. In extreme instances, bat culling has been proposed to minimize exposure; however, the ecological importance Dolutegravir mw of bats as a whole makes this an unrealistic option. In Malaysia and Australia efforts have been made to reduce livestock

interactions with bats; for example, restricting livestock access to areas under fruit trees, covering water and feed containers to prevent contamination and not placing water and feed under fruit trees (Anonymous, 2013a). However, the significant numbers of fruit trees and roosting flying foxes on or near properties containing

livestock makes complete separation of the wildlife and livestock populations near impossible. In Bangladesh, measures have been employed to prevent flying Progesterone foxes access to date palm sap collectors in hopes of preventing contamination with Nipah virus (Luby and Gurley, 2012). Unfortunately, Nipah outbreaks continue to occur every year reflecting the difficulty of implementing a new practice culturally to prevent such a disease that is still considered to be rare. Developing vaccines and antiviral therapies for Hendra and Nipah virus are also viable alternatives for mitigating disease risk. As livestock have been identified as intermediate hosts for both Hendra and Nipah virus, antiviral therapies seem less attractive given the size of horses and pigs and the significant costs associated with producing large quantities of any possible drug. Conversely, vaccination of livestock populations is a highly attractive mitigation strategy since both disease in the target species as well as secondary transmission of virus to humans would be prevented.