In this study, we aimed to evaluate the cardiac functions of CCHF patients.
Methods: This prospective study was performed among confirmed CCHF
cases in Turkey in 2007. All the patients underwent a thorough cardiologic evaluation and transthoracic buy MK-8931 echocardiography examination within 24 hours of hospitalization. In addition, the patients were classified into two groups – ‘severe’ CCHF and ‘non-severe’ CCHF. Demographic characteristics, findings of echocardiography, and outcomes were recorded for each patient.
Results: Among 52 consecutive patients with a tentative diagnosis of CCHF, 44 were confirmed as having CCHF. Seventeen (38.6%) patients were classified as severe, whereas the remaining 27 (61.4%) patients were classified as non-severe. Five of 17 severe CCHF patients died. Severe cases had a tower left ventricular ejection fraction (p = 0.04), a higher systolic pulmonary artery pressure (p = 0.02), and more frequent pericardial effusion (p < 0.001) compared to non-severe cases. Fatal https://www.selleckchem.com/HIF.html CCHF cases also had a lower left ventricular ejection fraction (p = 0.03), a higher systolic pulmonary artery pressure (p = 0.03), and more frequent pericardial effusion (p = 0.01) compared to survivors.
Conclusions: The results of this study indicate that severe and fatal CCHF
cases have impaired cardiac functions, which may be associated with fatality in CCHF infection. Direct invasion of the heart muscles by the virus or endothelial damage of cardiac structures may have a rote in this. Molecular testing methods would be useful in order to investigate direct invasion by the CCHF virus. Clinicians
should be aware of this complication. (C) 2008 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.”
“Background: Arterial hypertension AZD6244 and premature coronary, artery disease are poorly understood complications of cardiac transplantation in children. Arterial stiffness is associated with cardiovascular risk in adults. Pulse wave velocity (PWV) may be used as a surrogate for arterial rigidity. In this study We investigate PWV in children after cardiac transplantation.
Methods: Sitting blood pressure was Measured in 22 children (>6 months after transplantation) and 95 controls and PWV was measured using the SphygmoCor device by high-fidelity applanation tonometry at the carotid, radial and femoral arteries.
Results: The transplant group was significantly older than the control group (13.4 years vs 11.1 years; p 0.006), but there was no significant height or weight difference. The diastolic (but not systolic) pressure was significantly higher in the transplant group (75 ram Hg vs 65 mm Hg; p = 0.003). Aortic (carotid/femoral) PWV was significantly associated with age, height, weight (in the control group only) and systolic blood pressure according to univariate analysis, whereas brachial (carotid/radial) PWV was unrelated to these.