Failures were categorized as within the radiation field (locoregional failure) and outside the radiation field (distant failure).

Results: 57 patients (41.9%) reached complete remission after CCRT. Tumor location, uptake of positron emission tomography, esophageal obstruction, T staging, node staging, M staging(by 6th AJCC) before treatment, and consolidation chemotherapy were associated with complete remission after CCRT. At a mean follow-up duration of 20.3(±15.5) months, 74 patients (54.4%) had experienced selleck chemicals locoregional failure, 26 (19.1%) had outfield failure, and 35 (25.7%) had no evidence of failure. Esophageal obstruction before CCRT, residual tumor on first endoscopy after CCRT, and higher T stage on follow-up computed tomography were significantly associated with locoregional failure. Conclusion: About

70% of patients who had experienced treatment failure were locoregional failure after CCRT in esophageal SCC. Future therapeutic strategies such as high dose RT or additive surgical resection may be necessary to enhance local control, especially in the cases of esophageal obstruction before CCRT, residual tumor on the first endoscopy after CCRT, and higher T stage on follow-up computed tomography in esophageal SCC. Key Word(s): 1. SCC; 2. CCRT; 3. treatment failure; 4. Local control; Presenting Author: FAN YUJING Additional Authors: LAN YU Corresponding Author: FAN YUJING Affiliations: Beijing Jishuitan

Hospital Objective: Eosinophilic esophagitis(EE)is an uncommon disease characterized by focal or diffuse eosinophilic infiltration of the esophagus. NVP-BKM120 nmr The symptoms of EE is usually associated with dyspepsia, diarrhea and peripheral eosinophilia,but 上海皓元 obstraction is rarely. Methods: Mr W was a 62-year-old worker. 18 months ago, he suffered cerebral infarction and had motor aphasia caused by sequela. 17 months ago, he suffered bullous pemphigoid and began to received prednisone treatment. The maintenance treatment last so far and the dosage was decreased gradually to 10 mg qd.Since suffered cerebral infarction, he often presented with intermittent nausea and vomitting after meal but no attention was payed. His symptoms worsened and he developed vomtting after eating food or water immediately over the past two mo.EGD revealed esophageal longitudinal ulcer with partial distal esophageal obstruction. Histological examination of the biopsy from the esophagus demonstratedesophagitis with heavy eosinophilic infiltration. we give him barium X-ray examnition. It revealed that the muscal of lower esophagus was smooth. Based on the above findings, the diagnosis of eosinophilic esophagitis was made, The patient was started on prednisone 30 mg daily and responded promptly with resolution of symptoms.two weeks later, His eosinophil count decreaseed a lot and his symptoms continued to improve on maintenance steroids.