Exploratory laparotomy revealed that the tumor originated in the pancreas uncus and involved the root of the mesentery, which was deemed unresectable after an outside institution’s evaluation. As a result of our experience with intestinal transplantation, the patient was referred for further evaluation. On exploration, the tumor was 18 x 20 x 20 cm size involving the duodenum and head of the pancreas and encasing the superior mesenteric vessels. A 250-cm-long segment of ileum was found to be tumor free and was then harvested, perfused in the back table with UW preservation solution, and stored in ice. The descending

Inhibitor Library clinical trial colon was preserved on the vascular pedicle of the inferior mesenteric artery. The tumor was resected en bloc with the root of the mesentery, the head of the pancreas, the duodenum, and the ascending/transverse colon. The ileal segmental graft was then revascularized via the superior mesenteric artery stump and the transected distal superior mesenteric vein. Intestinal continuity was completed using a pancreaticojejunostomy, choledochojejunostomy, gastrojejunostomy, and ileocolostomy. The warm ischemic time was 3.5 min and the cold ischemic time was 50 min. Immunohistochemical markers BVD-523 cost established the diagnosis of a SPN. Results: Her postoperative course was uneventful, with resumption of oral diet on day 8. After 10-month follow-up, the patient remains in a good condition

without signs of tumor recurrence. Conclusion: Intestinal autotransplantation is potentially valuable option for a variety of lesions involving the mesenteric root, which were previously thought to be unresectable. Key Word(s): 1. auto-transplantation;

2. intestine; 3. pancreatic cancer; Presenting Author: QINGCHUAN Protein kinase N1 ZHAO Additional Authors: WEIZHONG WANG, HAI SHI, DONGLI CHEN, JIANYONG ZHEN, MIAN WANG, XIN WANG, GUOSHENG WU Corresponding Author: GUOSHENG WU Affiliations: Xijing Hospital of Digestive Diseases & State Key Laboratory of Cancer Biology, Fourth Military Medical University Objective: Intestinal transplantation has become a valid therapeutic option for patients with irreversible intestinal failure. Intestinal living donation offers several advantages, such as minimized preservation injury, better HLA matching, and possibly reduced incidence of rejection. We herein present our single-center experience over a 13-year period. Methods: From May 1999 to August 2012, 6 living donor intestinal transplants were performed in 6 patients (3 males, 3 females; average age 18 years old). All cases were ABO-identical except for one case from blood-type AB to B. All transplants were haplotype-match except for one case from husband to wife. All pre-transplant CDC cross-match was negative except for one case with a positive cross-match. A segment of distal ileum 180 to 200 cm was used. The immunosuppressive protocol consisted of induction with thymoglobulin and maintenance with tacrolimus with or without mycophenolate mofetil and steroids.