Bosscha MD, PhD; E Ritchie MD; M Vermeer, Bosch Medical Centre, Den Bosch; PW de Graaf MD, PhD; B van Etten MD, PhD; C Haazer (I); E Salm MD, PhD (I); selleck screening library Reinier de Graaf Hospital, Delft; B Lamme MD, PhD; EJ Hesselink MD, PhD; H Rommes MD, PhD (I), Gelre Hospitals, Lucas Hospital Apeldoorn; RJ Oostenbroek MD, PhD; L te Velde MD; G Govaert MD; HH Ponssen MD (I), Albert Schweitzer Hospital, Dordrecht; HG Gooszen MD, PhD; MK Dinkelman MD; LPH Leenen MD, PhD (I), University Medical Centre Utrecht; EGJM Pierik MD, PhD; KWW Lansink MD; J Bakker MD, PhD (I), Isala Clinics, Zwolle.
Key staff and steering committee at coordinating center RELAP trial:O van Ruler (investigator), EA Reuland (data management), CW Mahler (investigator), JB Reitsma (epidemiologist), CAJM de Borgie (epidemiologist), KR Boer (quality of life investigator), BC Opmeer (health economist), MA Boermeester (principle investigator, project supervisor, gastrointestinal surgeon) from the Department of Surgery, Academic Medical Center Amsterdam, The Netherlands.The key staff and steering committee received compensation from the grant provided by ZonMw, The Hague, The Netherlands.Financial support:Dutch Organization for Health Research and Development (ZonMw), The Hague, The Netherlands. Health Care Efficiency Program. Grant number: 945-02-028ZonMw approved the study protocol (including design and conduct of the study, data collection and management) after consulting national and international independent reviewers. Final analyses, interpretation of data, manuscript preparation, review and approval of the manuscript were left to the authors’ discretion and were not influenced in any way by ZonMw.
Supported by the Netherlands Organization for Health Research and Development (ZonMW), The Hague, The Netherlands. Grant no. 945-02-028.
Every day you may make progress. Every step may be fruitful. Yet there will stretch out before you an ever-lengthening, ever-ascending, ever-improving path. You know you will never get to the end of the journey. But this, so far from discouraging, only adds to the joy and glory of the climb.Winston ChurchillIntroductionCritical care medicine is a relatively young discipline that has rapidly grown into a full-fledged specialty. Demand for intensive care has steadily escalated, and the ratio of intensive care unit (ICU) to hospital beds is increasing everywhere. ICUs now hold a key position in all hospitals, and critical care physicians Drug_discovery are responsible for managing the ever-increasing numbers of patients with complex, life-threatening medical and surgical disease. Perhaps nowhere else in clinical medicine has the evolution of technology and scientific advance been so apparent and new ideas, concepts, and discoveries moved so fast from bench to bedside.