An occlusal interference can cause the alteration of muscular tonus, which can lead to pains in chewing and in the head and neck muscles. Patients Zotarolimus(ABT-578)? with no history of TMDs are less vulnerable to occlusal alterations;3 nevertheless, in vulnerable patients, the symptoms can be exacerbated if the occlusal adjustment of rehabilitations is wrongly performed, compromising the harmonic relation between the arches. If the trigeminal afferences and proprioception are altered, these disorders can generate, in descending action, into an imbalance of postural muscles chains, finally causing postural modifications.18 From the information gathered, it seems to be evident that occlusal interferences can lead to the development of or to an increase in the severity of TMDs.

Since occlusal therapy could induce a re-equilibrium of masticatory muscles, this re-equilibrium could influence, in descending action, the whole body��s postural muscles, resulting in an improved posture.18 Also, the relation between the upper and inner arches and the temporomandibular joint can generate alterations in the gaze stabilization and in the body posture, which indicate that the relevance of the occlusal adjustment on the treatment of TMDs should be reevaluated. The authors should clarify that not only occlusal adjustments can be considered in TMD treatment, but also the use of occlusal splints, psychological therapy, and physiotherapist treatment. Each case should be considered singly and analyzed according the clinical situation.

As a further consideration, adjustments should be conducted only after the influence of interferences on the disorder has been confirmed through evaluating the signs and symptoms, and never in a prophylactic manner.1 Finally, a multidisciplinary approach should be employed in order to provide the most correct treatment and to achieve a greater likelihood of success.
We read the paper by Huak1 with great interest. The author is to be congratulated for his view regarding the biostatistics. Although his paper is interesting, some considerations should be addressed. Huak1 suggested that when statistical significance was reached, the manuscript stood a better chance of getting published (scenario 1 and 3 in Table 3). In contrast, a study with negative (statistically insignificant) results would have a lower possibility of getting published if its probability value (P-value) was of >.

05 (scenario 2). A study that lacks both clinical and statistical significance would not merit inclusion in the literature (scenario 4). Indeed, this doctrine seems to be wrong. It contributes to the so-called ��positive outcome bias�� or ��pipeline bias��, Carfilzomib a common form of ��publication bias (PB)��. PB influences the chances of publication and the tendency of investigators, reviewers, and editors to submit or accept manuscripts for publication based on the direction or strength of the findings of quantitative studies.