A pupil has continued the general trend of his teacher’s studies

A pupil has continued the general trend of his teacher’s studies. His first research

there was devoted to the study of the pathogenesis of tetanus and mechanisms of tetanus toxin action. After years of research into the problem he was able to get direct evidence of tetanus toxin neural transport from the muscles to the central nervous system (CNS), which put an end to disputes about the ways of tetanus toxin receipt in see more the CNS. A fundamentally new was his definition of the tetanus nature as a complex polysistemic disease with involvement of different integrative systems and organs. These and other studies have been summarized in Kryzhanovsky’s doctoral thesis and two books of 1966: “Tetanus: The pathogenesis, clinical features, treatment, and recovery in the pathophysiological aspect” and “Tetanus”. While working with tetanus toxin and antibodies toward it, his team obtained first

“true anti-antibodies” or anti-idiotypes against anti-tetanus immunoglobulins. This pioneering work of his group (1960–1962) preceded analogous Western publications by J. Oudin for years.1 His priority in this field still has to be appreciated by world Immunology. In 1966 he became head of the Laboratory of infectious diseases of the nervous system (later – the Laboratory of General Pathology mTOR inhibitor of the nervous system), which Kryzhanovsky led to the last days of his life. In 1984, Professor G.N. Kryzhanovsky was elected a full member of the Academy of Medical Sciences Roflumilast of the USSR. From 1983 to 2001 he headed the Institute of General Pathology and Pathophysiology, keeping the good tradition established by his predecessors – the outstanding scientists A.D. Speransky, V.N. Chernigovsky, V.V. Parin, A.M. Chernukh. Until the end of his career he remained an Honorary Director of this Institute, giving to it all his creative powers. For his research achievements G.N. Kryzhanovsky awarded the State Prize of the USSR and the highest award of the Russian Academy of Medical Sciences – N.I. Pirogov Prize

and Medal. He also awarded a number of medals of foreign scientific societies and achieved orders of the USSR – the Order “Friendship”, the Order of Honors and “Badge of Honor”. G.N. Kryzhanovsky made a significant contribution to the organization and planning of national biomedical research, coordination of the scientific institutions of the Academy of Medical Sciences, being an Academician – secretary of the Presidium of the USSR Academy of Medical Sciences, member of the Presidium of the USSR and Russia’s Academy of Medical Sciences (since 1985 till 1995). He was Adviser to the Presidium of the Academy of Medical Sciences (1995–2001). Since 1982 till the last day of life he was the President of Soviet (later on – All-Russia’s) Society of Pathophysiologists. Thanks to his energy, commitment and a lot of scientific and organizational experience, G.N.

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