38%, p = 0.012). Multivariate analysis showed only HBV
DNA unde-tectability at month 24 was the independent predictor for long term VR (p=0.002). When Area Under the Receiver Operating Curve (AUROC) was compared between HBV DNA unde-tectability at month 12 and month 24, AUROC value of month 24 (0.898; 95% confidence interval [CI], 0.829-0.968; P <0.001) was higher than that of month 12 (0.842; 95% confidence interval [CI], 0.752-0.932; P <0.001). Conclusion: Long term ADV and LMV combination therapy lead to VR in a significant number of LMV resistant CHB patients with genotype C. However the efficacy PXD101 price was not satisfactory during long term treatment. Alternative therapy is certainly needed in patients who have detectable HBV DNA after month 24. Disclosures: Hyung Joon Yim – Grant/Research Support: GSK Korea, Handok Pharm, Gilead Korea; Speaking and Teaching: BMS Korea Chang Wook Kim – Consulting: Gilead;
Grant/Research Support: BMS, Boehringer Ingelheim, Pharmicell; Speaking and Teaching: BMS, GSK, Dae-woong Hee Bok Chae – Consulting: BMS-Korea, Gilead Science-Korea The following people have nothing to disclose: Hae Rim Kim, click here Sang Jun Suh, Yeon Seok Seo, Chang Don Lee, Sang Hoon Park, Myung Seok Lee, Choong Kee N. Park, Moon Young Kim, Soon Koo Baik, Yun Soo Kim, Ju Hyun Kim, Jung Il Lee, Jin-Woo Lee, Sun P. Hong, Soon Ho Um Aim: In this study, we aimed to investigate the antiviral efficacy of entecavir (ETC) therapy in chronic hepatitis B (CHB) patients with previous nucleos(t)ide analogue (NA) experience. Methods: Study inclusion criteria were being NA-naïve or previous NA-experience in the absence of lamivudine (LAM) resistance and receiving ETC therapy for at least 6 months. Biochemical and virological tests were obtained at baseline and 3-month intervals in
the first year and every 6 months thereafter. The primary outcome measure for efficacy was complete virological response (CVR), defined selleck kinase inhibitor as HBV-DNA<20 IU/ml. Estimated cumulative response rates were calculated by Kaplan-Meier analysis. Results: 211 patients (148 male, mean age 43.8±12.8, 58 HBeAg+ CHB, and 61 cirrhosis) were included in the study. 1 81 patients were NA-naïve and 30 patients had prior exposure to NAs. Among NA-experienced patients there were 9 patients with previous adefovir (ADF) failure, and the remaining had LAM experience without a history of virological breakthrough or LAM resistance. However, A1 81T/V mutation was detected in 4 patients with previous LAM experience, despite being naïve to ADF. LAM experienced patients received LAM at a median of 12 (6-48) months and patients with ADF failure were treated with ADF at a median of 24 (8-48) months. One patient with ADF failure received add-on combination therapy with ETC after a virological breakthrough and the remaining patients were switched to ETC due to suboptimal response.