25 cases were staged in TNM I to II, and 33 cases were staged in TNM III to IV. Immunohistochemistry was used to detect the expressions of CD68, IL-10, and IL-12 in gastric cancer and adjacent tissue. Results: The expression intensity of CD68, IL-10 in gastric carcinoma or in the inflammatory cells of gastric carcinoma was higher than the normal tissue beside carcinoma (P < 0.05), however, the expression intensity of IL-12 in the inflammatory
cells of gastric carcinoma was lower than the normal tissue beside carcinoma (P < 0.01). There is a positive correlation between CD68 in gastric carcinoma and IL-10 in inflammatory cells in gastric carcinoma GDC-0068 price (P < 0.05) and a negative correlation between CD68 and IL-12 by Spearman rank correlation analysis (P < 0.05). Conclusion: CD68 in gastric carcinoma may up regulate
IL-10 and down regulate IL-12, which explain that the macrophages in gastric carcinoma tissues may be M2 polarization macrophages. Key Word(s): 1. Gastric carcinoma; 2. CD68; 3. IL-10; 4. IL-12; Presenting Roscovitine solubility dmso Author: YANMINGGUO MINGGUO Additional Authors: WANG NONGRONG, FU XIAOJUN, XIE GUISHENG, FANG NIAN Corresponding Author: YANMINGGUO MINGGUO Affiliations: The fourth affiliated hospital of nanchang university Objective: To investigate the diagnostic value of serum CEA and C724 in intestinal cancer. Methods: Electricity chemiluminescence method to determine the intestinal cancer patients 19 cases of the CEA and CA724 serum level, and 81 cases of normal and as a control. Results: In 19 patients, the CEA level in blood serum was high in 11 patients and normal in 8 patients. the CA724 level in blood serum was high in 2 patients medchemexpress and normal in 17 patients. In 81 healthy controls, CEA level in blood serum was high in 4 cases and normal in 77 cases. the CA724 level in blood serum
was high in 8 cases and normal in 73 cases. Conclusion: the CEA level in blood serum were significantly higher than control groups (P = 0.05), It has very important Clinical diagnostic value in intestinal cancer. however, In our experiments, the CA724 level in blood serum were zero difference in experimental group and control groups (P = 0.05), CA724 as a Clinical diagnosis and colorectal cancer screening indicator’ value remains to be further studied in intestinal cancer. Key Word(s): 1. CEA; 2. CA724; 3. Intestinal cancer; Presenting Author: EIKI NOMURA Additional Authors: YU SASAKI, TAKESHI SATO, NANA KANNNO, MAKOTO YAGI, KAZUYA YOSHIZAWA, DAISUKE IWANO, YASUHIKO ABE, SYOICHI NISHISE, YOSHIYUKI UENO Corresponding Author: EIKI NOMURA, YU SASAKI, TAKESHI SATO, NANA KANNNO, MAKOTO YAGI, KAZUYA YOSHIZAWA, DAISUKE IWANO, YASUHIKO ABE, SYOICHI NISHISE, YOSHIYUKI UENO Affiliations: Depertment of Gastroenterology, Yamagata University Objective: Amyloidosis is a rare disorder, defined as the extracellular deposition of an abnormal fibrillar protein, which disrupts tissue structure and function.