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calculations. AA and YH participated in the sequence alignment and drafted the manuscript. SWJ supervised HKI-272 cell line the whole study. All authors read and approved the final manuscript.”
“Background Developing bright luminescent probes is still one of the targets for achieving better optical imaging quality [1, 2]. With respect to www.selleckchem.com/products/pci-34051.html cellular imaging, the combination of a specific targeting group and the selective response to an analyte is the key to an effective probe design [3, 4]. Even though numerous bio-imaging

probes have been developed in the last few decades [5], the organic fluorophores used for signaling still suffer from low probe brightness, poor photostability, and oxygen bleaching [6, 7]. Consequently, Montelukast Sodium the creation of fluorophores with improved photophysical properties is still in high demand [1, 2]. Semiconductor quantum dots (QDs), on the other hand, have been produced to overcome the drawbacks of organic fluorophores [2, 8], but they are not sufficiently biocompatible due to their large size, intermittent photon emission, and potential toxicity [9]. Silver nanodots (AgNDs), however, are one of the most notable alternatives to current fluorophores. AgNDs are small, few-atom clusters that exhibit discrete electronic transitions and strong photoluminescence [10, 11]. After the report of the first stable silver nanodots in aqueous solution in 2002 [12], many scaffolds have been developed, for example, based on poly(acrylic acid) [13] or short peptides [14], which stabilize the reduced silver atoms. Among these scaffolds, DNA stabilization has induced the best photophysical characteristics of AgNDs, such as high molar extinction coefficients, high emission quantum yields, and noticeably high photostability.