Patrick DL, Burke LB, Gwaltney CJ, Leidy NK, Martin ML, Molsen E, Ring L (2011) Content validity—establishing and reporting the evidence in newly

developed patient-reported outcomes (PRO) instruments for medical product evaluation: ISPOR PRO Good Research Practices Task Force report: part 2—assessing respondent understanding. Value Health 14:978–988PubMedCrossRef 20. Joffe H, Yardley L (2004) Content and thematic analysis. In: Marks D, Yardley L (eds) Research methods for clinical and health psychology. Sage, London, pp 56–68 21. Kerr C, Nixon A, Wild D (2010) Assessing and demonstrating data saturation in qualitative inquiry supporting patient-reported outcomes research. Expert Rev Pharmacoecon Outcomes Res 10:269–281PubMedCrossRef 22. Willis GB (2005) Cognitive interviewing: a tool for improving questionnaire KU55933 order design. Sage, Thousand Oaks 23. Tosteson AN, Hammond CS (2002) Quality-of-life

assessment in osteoporosis: health-status and preference-based measures. Pharmacoeconomics 20:289–303PubMedCrossRef 24. Lewiecki EM (2009) Current and emerging pharmacologic therapies for the management of postmenopausal osteoporosis. J Womens Health (Larchmt) 18:1615–1626CrossRef”
“Introduction Teeth and bones are regarded the most mineralized tissues in humans. Several reports suggest association between tooth loss or small number of remaining teeth and reduced bone mineral density (BMD) [1–5]. There is also evidence of the effect of periodontal disease and osteoporosis in the elderly [6–11]. Furthermore, periodontal Verubecestat ic50 disease has also been reported an important and common coincidence of systemic bone loss in both women and men [12–16]. It has been shown that the reduction of systemic BMD may be a risk {Selleck Anti-infection Compound Library|Selleck Antiinfection Compound Library|Selleck Anti-infection Compound Library|Selleck Antiinfection Compound Library|Selleckchem Anti-infection Compound Library|Selleckchem Antiinfection Compound Library|Selleckchem Anti-infection Compound Library|Selleckchem Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|buy Anti-infection Compound Library|Anti-infection Compound Library ic50|Anti-infection Compound Library price|Anti-infection Compound Library cost|Anti-infection Compound Library solubility dmso|Anti-infection Compound Library purchase|Anti-infection Compound Library manufacturer|Anti-infection Compound Library research buy|Anti-infection Compound Library order|Anti-infection Compound Library mouse|Anti-infection Compound Library chemical structure|Anti-infection Compound Library mw|Anti-infection Compound Library molecular weight|Anti-infection Compound Library datasheet|Anti-infection Compound Library supplier|Anti-infection Compound Library in vitro|Anti-infection Compound Library cell line|Anti-infection Compound Library concentration|Anti-infection Compound Library nmr|Anti-infection Compound Library in vivo|Anti-infection Compound Library clinical trial|Anti-infection Compound Library cell assay|Anti-infection Compound Library screening|Anti-infection Compound Library high throughput|buy Antiinfection Compound Library|Antiinfection Compound Library ic50|Antiinfection Compound Library price|Antiinfection Compound Library cost|Antiinfection Compound Library solubility dmso|Antiinfection Compound Library purchase|Antiinfection Compound Library manufacturer|Antiinfection Compound Library research buy|Antiinfection Compound Library order|Antiinfection Compound Library chemical structure|Antiinfection Compound Library datasheet|Antiinfection Compound Library supplier|Antiinfection Compound Library in vitro|Antiinfection Compound Library cell line|Antiinfection Compound Library concentration|Antiinfection Compound Library clinical trial|Antiinfection Compound Library cell assay|Antiinfection Compound Library screening|Antiinfection Compound Library high throughput|Anti-infection Compound high throughput screening| factor for the development of tooth loss and oral health problems [2, 7, 17] suggesting possible cause–effect link, particularly in postmenopausal women with osteoporosis [13, 18, 19]. Some studies also show that dental status impairment related to osteoporosis may

result from a considerable decrease of mandibular bone mass [20, 21], though the contributing factors remain unclear. Possible mechanisms may include tooth loss during ageing as a natural process secondary to the systemic bone loss; however, the age-related progressive dental decline may ifoxetine also co-exist with deficits in BMD [17, 21]. These associations are well recognized among the elderly but there are still limited data on such associations in younger age. Accelerated tooth wear appears one of the conditions affecting enamel, independently of age, so that it may occur in younger otherwise healthy people. It is well known that tooth enamel is the hardest tissue in the human body. Although enamel does not have the typical structure of human bone, its chemical composition is similar. Hydroxyapatite and magnesium phosphate are building minerals essential for bone structure, quality, and resistance whereas some trace elements (i.e.