Approximately 20% of adolescents and children are overweight. Moreover, 30% of those who are overweight actually fulfill the criteria of obesity. The epidemic of obesity results in substantial economic burden. It is currently responsible for 2-8% of healthcare costs and 10-13% of deaths in various parts of Europe [1]. Being overweight is a well-established risk factor of many chronic diseases, such as diabetes, hypertension and other cardiovascular diseases [2]. Survivors of pediatric acute lymphoblastic leukemia

(ALL) are at substantially increased risk of developing obesity [3–5]. The most common explanations involve late effects of chemo-and radiotherapy, treatment with corticosteroids, Eltanexor supplier altered life style, with prolonged

periods of relative immobility and decreased energy expenditure. Leptin is a hormone synthesized mostly by white adipose tissue. Its structure is similar to cytokines. It plays a role of peripheral signal informing of the energy storage and thus participates in the long-term regulation of appetite and the amount of ingested food [6]. Plasma levels of leptin depend directly on adipose tissue mass and correlate with body mass index (BMI) [7]. Central and peripheral effects of leptin are mediated by leptin receptors located on cell surface [8]. Several isoforms of long selleck compound form and short forms of leptin receptors are expressed in humans. The long form of leptin receptor is expressed primarily in the hypothalamus, and the short forms of leptin receptor are typical for peripheral tissues. Soluble leptin receptor is a unique form, which consists solely of extracellular domain of membrane leptin receptors [9]. By binding to this receptor, leptin delays its clearance from circulation [10]. This results in increased leptin levels and bioavailability and, as a consequence, potentiates its effect [11]. On the other hand, the plasma levels of soluble leptin receptors correlate with density of the leptin receptors on cell membranes [12]. In obese children with no TGF-beta inhibitor comorbidities the levels of leptin are

higher and the levels of soluble leptin receptor are lower than in non-obese children [13]. Therapy of ALL (chemo- and/or radiotherapy) may permanently modify the secretion of leptin and levels of check details leptin receptors [5]. Among the hereditary risk factors, the polymorphisms of leptin or leptin receptor genes provide a good opportunity to study the relationship between ALL and overweight status. To our knowledge there were no studies investigating polymorphisms of leptin and leptin receptor genes and their products in ALL survivors. Therefore, the aim of our study was to determine the polymorphisms of leptin and leptin receptor genes and plasma levels of leptin and leptin soluble receptors in survivors of childhood ALL.