9 months (range, 1445 months) HBV reactivation

9 months (range, 1445 months). HBV reactivation learn more was observed in three patients, one of whom required antiviral treatment. No HBV reactivation-related hepatitis was observed. In conclusion, prevention of HBV reactivation by monitoring of HBV viral load is cost-effective and may decrease the risk of developing drug resistance from routine anti-HBV prophylaxis

treatment. It can be considered as an alternative in psoriasis patients treated by TNF-a inhibitors, especially in areas with a high HBV burden and in hepatitis B e-antigen-negative patients who have a lower risk of viral reactivation.”
“Objectives: To examine the level of agreement between self-reported and hospital administration records of arthritis-related surgeries for two large samples of community-dwelling older women in Australia, born between 1921-1926 and 1946-1951.

Study Design and Setting: Self-report survey data from the Australian Longitudinal Study on Women’s Health was linked to inpatient hospital data from the New South Wales Admitted Patient Data Collection. Levels of agreement were compared using Cohen’s kappa, sensitivity, specificity,

and positive and negative predictive values. Reasons for false positives were AMN-107 examined.

Results: This study found good agreement (kappa >0.70; sensitivity ‘and specificity >0.80) between self-report and hospitalizations data for arthritis-related surgeries.

Conclusions: This study provides new evidence for good agreement between self-reported selleck compound health survey data and administrative records of arthritis-related joint procedures, and supports the use of self-report surveys in epidemiological studies of joint procedures where administrative data are either not available or not readily accessible, or where more extensive contextual information is needed. The use of health survey data in conjunction with administrative data has an important role to play in public health

planning and policy. (C) 2013 Elsevier Inc. All rights reserved.”
“Frail older adults have a high prevalence of chronic pain with major effects on function and quality of life. Many analgesics, including opioids, have adverse effects on older adults with multiple co-morbidities. Methadone has been increasingly used for analgesia in the last 10 years. However, a number of adverse events such as sleep-disordered breathing, methadone-induced torsades de pointes arrhythmias, as well as the “”addiction stigma,”" have made people reluctant to use this medication.

This article uses examples of five cases of pain in frail older adults living in a skilled nursing facility.

Safe and effective use of methadone is illustrated with these cases. The pharmacology of methadone in frail elders is reviewed to demonstrate the specific benefits of the drug in older adults and how adverse events can be minimized.

Methadone is an excellent choice for pain in frail older adults.

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